HMGCS1HMGCS1 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 1) is a Protein Coding gene. Among its related pathways are Terpenoid backbone biosynthesis and Regulation of cholesterol biosynthesis by SREBP (SREBF). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and isomerase activity. An important paralog of this gene is HMGCS2.
Full Name 3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 Function Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. Biological Process Acetyl-CoA metabolic process Source: GO_Central Cholesterol biosynthetic process Source: Reactome Farnesyl diphosphate biosynthetic process, mevalonate pathway Source: GO_Central Lipid metabolic process Source: ProtInc Cellular Location Cytoplasm
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