Antibodies may generate a variety of degradants during production, processing, and storage both in liquid and solid states. The tendency of antibodies to generate such degradants depends very much on their amino acid sequences, pI, hydrophobicity, and carbohydrate content. The antibody degradation products may have reduced activity but increased immunogenicity. The major purpose of formulating antibodies is to reduce the rate of antibody degradation to provide acceptable shelf life for shipping and storage. This can be done by choosing proper formulation conditions. It should be emphasized that one formulation excipient stabilizing a specific antibody may not be suitable for another one for the differences in their sequences. Moreover, excipients could alter the immune response by changing the presentation of the proteins, such as the spacing of epitopes. A proper formulation composition not only maximally preserves the activity of the antibody but also minimizes the potential immune response. Learn more: antibody formulation
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